neuroinflammation in retinal degeneration

A collaboration of researchers from Wayne State University, the Mayo Clinic and Johns Hopkins Medicine has discovered a potential new treatment for macular degeneration and retinitis pigmentosa. The investigators managed to attach steroids to dendrimers nanoparticles and showed that the drugs only targeted the activated microglia, the damage-causing cells associated with neuroinflammation. The researchers published their article online in the journal Biomaterials.eye-close-up

Age-related macular degeneration and retinitis pigmentosa are leading causes of blindness worldwide. Neuroinflammation plays a big role in both diseases. Activated microglia release substances that damage certain cells in the retina, which eventually can lead to vision loss.

Because steroids have neuroprotective and anti-inflammatory properties, the researchers tried to deliver them precisely to the right target. Therefore they used polyamidoamine dendrimers as drug delivery vehicles, which are about 3-10 nm in size. The activated microglia in the degenerating retina turned out to eat the dendrimers selectively and retain them for at least a month. The drug is slowly released from the dendrimer, offering neuroprotection to the retina.

Source:http://medgadget.com/2011/12/nanoparticles-to-deliver-steroids-to-the-retina.html

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