Medical Diagnostic Tool

Sandia’s Ulrich Schaff holds a prototype SpinDx, a portable instrument that can determine a patient’s white blood cell count, analyze important protein markers, and achieve results from other tests in a matter of minutes.

The SpinDx platform has several advantages:

  • Small sample size: Patients merely have to provide a pin-prick sample of blood.
  • Ease of use: The device uses a spinning disk, much like a CD player, to manipulate a sample. The disks contain commercially available reagents and antibodies specific to each protein marker.
  • Custom applications: Singh envisions a “plug and play” approach whereby the physician chooses among a “cardiac disk,” “immune disk” and similar options.
  • Inexpensive technology: The disks — the crux of the technology — cost pennies to manufacture.
  • Quick response time: Results can be delivered to the physician’s computer in 15 minutes.

“We envision medical personnel using SpinDx routinely,” said Greg Sommer, the Sandia researcher who spearheaded development of the project. “Instead of standard blood panels and costly lab tests, a SpinDx disk would be processed right in the office while the medical office staff is gathering routine data like temperature and blood pressure.”

Click on the thumbnail to view video footage of the “SpinDx” medical diagnostic tool. (Or view in HD on YouTube.)

The platform also has homeland security and food processing applications.

Singh recently led a National Institutes of Health grant (grant # 1U01AI075441) to adapt the lab-on-a-disk platform for toxin diagnostics.

The device could be the most accurate method available to detect the botulinum toxin, said Sommer. Caused by the bacteria Clostridium botulinum, the botulinum toxin is one of the most toxic substances known—a miniscule quantity can deliver a lethal dose. But despite scientific advances, laboratory mice remain the only reliable way to test for botulism.

“The mouse bioassay is primitive, but remains the gold standard due to its sensitivity,” Sommer said. “Our SpinDx botulinum assay vastly outperformed the mouse bioassay in head-to-head tests, and requires absolutely no animal testing. Plus there are a lot of cost and speed advantages.”

While botulism is quite rare — only about 145 cases are reported in the United States each year, according to the Centers for Disease Control and Prevention — the lethality of the toxin makes it an attractive candidate for bioterrorism. “A very small amount in the food system could harm a lot of people,” said Sommer.

Sandia’s goal, Sommer said, is to create a handheld, point-of-care device that can be used in the field by emergency responders.

SpinDx technology uses a spinning disk, much like a CD player, to manipulate samples. The disks cost mere cents to manufacture. (Photo by Randy Wong) Click on thumbnail for a high-resolution image.

SpinDx’s ability to process many substances also makes the device relevant for food safety testing. About 15 percent of botulism cases are food-borne. In 2007, 14 people in seven states contracted botulism from chile sauce due to faulty manufacturing equipment at a food plant in Georgia.

The Sandia team made improvements to the assay that enabled it to handle thick, viscous food substances. Collaborators at the U.S. Department of Agriculture provided high-quality botulinum antibodies that bind with high affinity, enabling higher sensitivity.

“Food processing plants are looking for something that can be integrated into their assembly lines,” said Sommer. “Our device will be suitable because it’s fast, inexpensive and simple to operate.”

The team is developing a deployable prototype to run the assays, with the goal of a fully integrated, automated device for field testing. “We’ve done most of our testing in a benchtop setting, where we spin the sample on the disk and then read it out on a microscope,” Sommer explained. “The next step is to automate those processes and get the system into users’ hands. SpinDx has a lot of potential for so many applications.”

Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin company, for the U.S. Department of Energy’s National Nuclear Security Administration. With main facilities in Albuquerque, N.M., and Livermore, Calif., Sandia has major R&D responsibilities in national security, energy and environmental technologies and economic competitiveness.

Sandia news media contact: Mike Janes, mejanes@sandia.gov (925) 294-2447

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