Archive for December 24th, 2016

Portable Antibiotic Resistance Detector Developed

Portable Antibiotic Resistance Detector Developed

antimicrobial-test

 

Researchers at University of California, Los Angeles developed a smartphone attachment capable of identifying whether a sample of a given bacteria is resistant to a particular antibiotic. The technology may have great potential for use in areas susceptible to the spread of infectious diseases when expensive laboratory equipment is not available.

There are 96 chambers within the device, each containing a bacterial sample mixed with a dose of an antibiotic and given time to react to the medicine. An array of LEDs illuminates the samples while the phone’s camera captures images of how light passes through the sample chambers using a special app. These images are then transferred to a remote computer server that analyzes them and sends the final results back to the app. Once the bacterial samples are placed into the device, the actual testing takes only a few minutes.

The researchers tested the device by trying 17 different antibiotics on the Klebsiella pneumoniae bacterium gathered from 78 different patient samples. They showed that their portable detector has an accuracy of 98.2%, high enough to be used in clinical practice.

“This mobile reader could eliminate the need for trained diagnosticians to perform antimicrobial susceptibility testing, reduce the cost barrier for routine testing, and assist in tracking of bacterial resistance globally,” said Omai Garner, UCLA assistant professor of pathology and laboratory medicine in Health Sciences who worked on the new device.

Open access study in journal Scientific ReportsHigh-throughput and automated diagnosis of antimicrobial resistance using a cost-effective cellphone-based micro-plate reader…

More from UCLA…

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NeuroMetrix Quell Neurostimulator for Day and Night Use Now Cleared in Europe

NeuroMetrix Quell Neurostimulator for Day and Night Use Now Cleared in Europe

quell

 

Quell, the pain-reducing neurostimulator that can be worn at night from NeuroMetrix, a Waltham, MA firm, received European regulatory approval to be marketed direct to consumers. The device, which we reviewed earlier this year, has the only FDA clearance in the United States to be used by consumers while sleeping to help manage pain. It features an accelerometer that recognizes when patient is in bed and the device adjusts therapy so it doesn’t keep patients awake, and yet disrupts pain signals. The Quell connects to a smartphone or tablet via Bluetooth, and can be controlled wirelessly using its own app.quell_device

It can be wrapped around the back, legs, or arms, to target whichever source of pain needs attention. We tested it ourselves and had a couple folks with chronic pain try it as well. This was certainly not a scientific study and you should really consult with your physician before trying the Quell, but do check out our reviewto get a good idea of this device.

https://youtu.be/1st-ktEmsYMSonar-System-for-blind

Flashbacks: Hands-On With Quell Wearable Pain Relief Device…Quell Smartphone Controlled Pain-Relieving Neurostimulator…More About Quell, NeuroMetrix’s Smartphone-Connected Neurostimulator…

Product page: Quell…

Via: NeuroMetrix…

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Scientists Built Blood-Brain Barrier On-a-Chip to Help Develop Neuro Drugs, Understand Brain Diseases

Scientists Built Blood-Brain Barrier On-a-Chip to Help Develop Neuro Drugs, Understand Brain Diseases

blood-brain-barrier

 

At Vanderbilt University researchers have developed a mimic of the blood-brain barrier in the form of a microfluidic device. To show a proof-of-concept of this “organ-on-chip” technology, the team studied how inflammation affects the blood-brain barrier continuously for an extended period of time, while previous approaches have only provided discrete snapshots of the process.

vanderbilt-organ-on-a-chipThe device is called NeuroVascular Unit (NVU) on a chip and it consists of a tiny space separated by a porous membrane. On top of the membrane is the “brain” side and the bottom is the “blood” side. Each of the sides has input and output tubes driven by micropumps that can sample the insides and deliver nutrients, drugs, pathogens, and anything else involved in an experiment.

To actually create a true blood-brain barrier, human endothelial cells are introduced on the “blood” side after flipping the device. Then fluid is pumped through the chamber with the cells. Interestingly, the cells begin aligning parallel with the direction of flow, creating an even layer of organized cells that resemble the structure of the blood-brain barrier. After two days of this, the cells are aligned and attached to the membrane separating the chambers. The device is flipped and astrocytes, pericytes, and excitatory neurons, which are also present in the barrier, are then added to the “brain” side of the device. The newly added cells slowly move through the membrane separating the chambers, interacting and sticking to the endothelial cells on the other side, resulting in perhaps the closest laboratory copy of the blood-brain barrier.

Here’s a Vanderbilt video discussing the new device:

Via: Vanderbilt…

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