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Musculoskeletal and connective tissue myopathy rhabdomyolysis was reported and in some of the reports, clarithromycin was administered concomitantly with statins, fibrates, colchicine or allopurinol see contraindications and warnings and precautions .

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However, based on published case reports that indicate the presence of colchicine toxicity when colchicine is co-administered with strong to moderate cyp3a4 inhibitors such as clarithromycin, erythromycin, grapefruit juice, etc.

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Hydroxymethylglutaryl coenzyme a reductase inhibitors statins and colchicine are known to cause myopathy.

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The xflow lc-arc system allowed facile radiometric detection of the five known colchicine metabolites in the current study.

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moreover, the few case reports of colchicine toxicity in the literature were the result of accidental overdose, 3 inappropriate intravenous administration, 4 or interactions with other drugs.

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