Archive for ‘Medical Software’

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iHealth Launches New Wristworn Pulse Oximeter, Ambulatory Heart and Blood Pressure Monitors at CES 2014

iHealth Launches New Wristworn Pulse Oximeter, Ambulatory Heart and Blood Pressure Monitors at CES 2014

iHealth pulse oximeter iHealth Launches New Wristworn Pulse Oximeter, Ambulatory Heart and Blood Pressure Monitors at CES 2014

iHealth Launches New Wristworn Pulse Oximeter,

Ambulatory Heart and Blood Pressure Monitors at CES

2014 …….

 

iHealth ;(Mountain View,CA), a subsidiary of China-based Andon Health, launched a new wristworn pulse oximeter, an ambulatory heart monitor, it is a very useful and an ambulatory blood pressure monitor at CES 2014. The pulse oximeter continuously measures blood -oxygen saturation (SpO2) and pulse rate at the finger tip, and is connected to a wrist strap that has an LED display showing the readings. The device also works via Bluetooth to the iHealth iOS app to display and track blood oxygen levels over time. Like other pulse oximeters, the device works by projecting two light beams, one red and the other infrared, onto the blood vessels in the finger. Oxygenated blood absorbs more infrared light and allows more red light to pass through, whereas deoxygenated blood absorbs more red light and allows more infrared light to pass through. A photodetector opposite the light emitters measures the ratio of red to infrared light received and from that calculates the amount of oxygen in the blood.iHealth.

ihealth bmp iHealth Launches New Wristworn Pulse Oximeter, Ambulatory Heart and Blood Pressure Monitors at CES 2014The second device unveiled by iHealth is an ambulatory heart rhythm monitor that is attached to the user chest using an adhesive patch. The monitor syncs with an iOS device using Bluetooth connectivity and displays a complete ECG on the user phone.

The device is capable of notifying the user of any arrhythmia and will be able to convey this information to a loved one or a caregiver. The device can save up to 72 hours of ECG data, and may one day serve as an option over Holter monitors for arrhythmia detection.

iHealth blood pressure monitor iHealth Launches New Wristworn Pulse Oximeter, Ambulatory Heart and Blood Pressure Monitors at CES 2014The third device launched by iHealth is an ambulatory blood pressure monitor that connects to a wearable blood pressure vest. The monitor is able to continuously track the wearer’s blood pressure without disturbing the user’s normal activity. It is able to connect to Android and iOS phones through Bluetooth 4.0 and can save up to 200 blood pressure readings. The blood pressure measurements can be registered in preset intervals, starting at every 15 minutes, or the user can have the device measure blood pressures at longer intervals of every 2 hours. The device is targeted at addressing the need for a continuous blood pressure monitoring device to better understand and track hypertension.

Both the iHealth ambulatory heart monitor and the ambulatory blood pressure monitor are not yet cleared by FDA.

Company page: iHealth…

Press release: IHEALTH ANNOUNCES THREE NEW WEARABLE MOBILE PERSONAL HEALTH PRODUCTS AT CES 2014

 

 

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New Method Helps Track Stem Cells in Body

New Method Helps Track Stem Cells in Body

New Method Helps Track Stem Cells in Body

Dr Lara Bogart uses a photothermal microscope to examine live stem cells

Researchers at the University have developed new methods to track stem cells and further understanding of what happens to them after they have been in the body for a significant period of time.

Stem cells are used to treat conditions such as leukaemia and have the potential to treat many more diseases and disorders where patient survival is reliant on organ and tissue donation. Currently, however, it is difficult for medics to establish whether stem cells have survived following transplantation in the body and if they reach their target site or migrate elsewhere.

In order to track stem cells in the body scientists use superparamagnetic iron oxide nanoparticles (SPIONs) to ‘label’ the cells before they are administered into the patient. These particles can be picked up by magnetic resonance imaging (MRI) scans and help medics establish if the stem cells reach their intended target. Conditions within the body’s cells, however, can lead to the degradation of SPIONs and reduce the ability of MRI scans to pick up on their signal in the long-term.

Scientists at Liverpool are developing methods to visualise SPIONs in the cells before they enter the body to learn where the particles are going within the stem cell and help predict how they might perform once they are inside the body over a long period of time. They are using a photothermal technique, a unique optical imaging system, to improve SPION labelling so that particles survive for longer and have minimal impact on the function of the transplanted cells.

Effective monitoring

Dr Lara Bogart, from the University’s Institute of Integrative Biology, said: “Stem cells have the potential to replace and repair damaged tissue to preclude the need for a patient to wait for an organ or tissue transplant. Research is ongoing into how it could be used to treat a wide variety of diseases such as Alzheimer’s, Parkinson’s disease, and type one diabetes.

“In order to fully explore this potential, however, more technological developments are needed to understand how stem cells behave in the body after transplantation. If we can’t monitor stem cells effectively, it can have serious implications for patient health. Studies have already shown that if cells migrate to the circulatory system, beyond their target organ or tissue site, then it can cause inflammation in the body.

“Labelling stem cells is hugely valuable to tracking their movements in the body, but we need to know more about how the particles used interact with stem cells. Using new imaging systems we can work out their precise location in the cell and how they behave over time. We hope to use this information to improve understanding of the MRI signal that tracks SPIONs once stem cells have been transplanted.”

The research, supported by Engineering and Physical Research Council (EPSRC), is published in the journal, ACS Nano. The full article can be accessed here.

One Response to “Tracking stem cells in the body”

Photothermal Microscopy of the Core of Dextran-Coated Iron Oxide Nanoparticles During Cell Uptake

A detailed understanding of cellular interactions with superparamagnetic iron oxide nanoparticles (SPIONs) is critical when their biomedical applications are considered. We demonstrate how photothermal microscopy can be used to follow the cellular uptake of SPIONs by direct imaging of the iron oxide core. This offers two important advantages when compared with current strategies employed to image magnetic cores: first, it is nondestructive and is therefore suitable for studies of live cells and, second, it offers a higher sensitivity and resolution, thus allowing for the identification of low levels of SPIONs within a precise subcellular location. We have shown that this technique may be applied to the imaging of both cell monolayers and cryosections. In the former we have demonstrated the role of temperature on the rate of endocytosis, while in the latter we have been able to identify cells labeled with SPIONs from a mixed population containing predominantly unlabeled cells. Direct imaging of the SPION core is of particular relevance for research involving clinically approved SPIONs, which do not contain fluorescent tags and therefore cannot be detected via fluorescence microscopy.

Source : https://news.liv.ac.uk/2012/06/21/tracking-stem-cells-in-the-body/

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Diabetes Management done with OneTouch® Verio™IQ Meter

Diabetes Management done with OneTouch® Verio™IQ Meter

 Included in the OneTouch® Verio™IQ Meter

 

  • OneTouch® Verio™IQ Meter with rechargeable battery
  • AC adaptor
  • Mini USB cable
  • OneTouch® Delica® Lancing Device
  • OneTouch® Delica® Lancets
  • Owner’s Booklet
  • Get Started Guide
  • Carrying case

OneTouch® Diabetes Management Software Systems Requirements Page

  • High speed Internet access highly recommended for download
  • A OneTouch® Meter with a data port.
  • A Windows®-compatible computer with the following components:
    • 266 MHz, Intel® Pentium® II processor or equivalent (higher is recommended)
    • Minimum 128MB of RAM (higher will help overall performance)
    • Minimum free hard disk space: 100-200MB during installation, 100MB for after installation
  • Microsoft® Windows® XP Home and Professional (SP2 or above), Windows Vista™, or Windows 7
  • A USB port
    • A OneTouch® Interface Cable required for OneTouch® meters only,
  • Mouse/Trackball
  • Keyboard
  • Windows®-compatible printer (recommended if you wish to print reports; colour printer recommended if you wish to print in colour)
  • Video monitor with at least 800×600 pixel screen resolution and 256 colours
  • CD-ROM drive or Internet connection

To order the CD Kit

Customers who prefer not to download OneTouch® Diabetes Software at no charge can purchase a CD Kit for $25 (price includes shipping, handling, and all applicable taxes). For more information, please call our OneTouch®Customer Care Line at 1 800 663-5521.

Please Note

  • A OneTouch® Interface Cable is required to download meter data from OneTouch Meters. To Purchase the OneTouch Interface Cable, please phone our Customer Care Line at 1 800 663-5521 Monday to Friday, 9 a.m. – 8 p.m. Eastern Time (6 a.m. – 5 p.m. Pacific Time).
  • Users must ensure that Regional Options are set to English is using the English version of OneTouch® Diabetes Software v.2.3.2 or above and set to French, if using the French version of the software
  • You must have Adobe® Reader® 5.0 or higher to view the OneTouch®Diabetes Software User Guide .

Product page: OneTouch VerioIQ Meter

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Single-Site(TM) Instrumentation for the da Vinci(R) Si(TM) Surgical System

Single-Site(TM) Instrumentation for the da Vinci(R) Si(TM) Surgical System

Intuitive Surgical Announces New Single-Site(TM) Instrumentation for the da Vinci(R) Si(TM) Surgical System
SUNNYVALE, Calif., Dec. 12, 2011 (GLOBE NEWSWIRE) — Intuitive Surgical, Inc. (Nasdaq:ISRG), the global leader in minimally invasive robotic-assisted surgery, today announced that it received FDA clearance to market its Single-Site Instrumentation for laparoscopic cholecystectomy procedures, the surgical removal of the gall bladder.
Single-Site Instrumentation provides da Vinci Si customers with a technology that enables cholecystectomy via a single incision, while providing the benefits of traditional multi-port da Vinci Surgery— enhanced surgical precision, control and stability and 3D HD visualization.
The Single-Site suite of instruments and accessories consists of the Single-Site Port, specialized curved cannulae and 5mm semi-rigid instruments, which are compatible with any da Vinci Si Surgical System. The design of the instruments and the da Vinci System’s Remote Center Technology are intended to reduce instrument crowding and external collisions typically associated with hand-held, laparoscopic single-incision devices.
Gary Guthart, CEO, Intuitive Surgical Inc., stated, “We are pleased with this clearance for our Single-Site instruments for use in laparoscopic cholecystectomy using the da Vinci System. We plan to immediately initiate a controlled rollout of these products in the US, while continuing our rollout in Europe. As we learn more about our customers’ needs within single-incision surgery, we anticipate future submissions to the US FDA and other global regulatory agencies related to expansion of the cleared indications for use, as well as additional Single-Site instruments.”
All da Vinci Si Surgical Systems are compatible with Single-Site™ Technology. The standard da Vinci and the da Vinci S Systems are not compatible with Single-Site Technology.
About Intuitive Surgical, Inc.
Intuitive Surgical, Inc. (Nasdaq:ISRG), headquartered in Sunnyvale, California, is the global technology leader in robotic-assisted, minimally invasive surgery (MIS). Intuitive Surgical develops, manufactures and markets robotic technologies designed to improve clinical outcomes and help patients return more quickly to active and productive lives. The company’s mission is to extend the benefits of minimally invasive surgery to the broadest possible base of patients. Intuitive Surgical — Taking surgery beyond the limits of the human hand.™
About the da Vinci Surgical System
The da Vinci Surgical System is a breakthrough surgical platform designed to enable complex surgery using a minimally invasive approach. The da Vinci Surgical System consists of an ergonomic surgeon console or consoles, a patient-side cart with three or four interactive robotic arms, a high-performance vision system and proprietary EndoWrist instruments. Powered by state-of-the-art robotic and computer technology, the da Vinci Surgical System is designed to scale, filter and seamlessly translate the surgeon’s hand movements into more precise movements of the EndoWrist instruments. The net result is an intuitive interface with breakthrough surgical capabilities. By providing surgeons with superior visualization, enhanced dexterity, greater precision and ergonomic comfort, the da Vinci Surgical System makes it possible for more surgeons to perform minimally invasive procedures involving complex dissection or reconstruction. This ultimately has the potential to raise the standard of care for complex surgeries, translating into numerous potential patient benefits, including less pain, a shorter recovery and quicker return to normal daily activities.
Intuitive®, Intuitive Surgical®, da Vinci®, da Vinci® S™, da Vinci® S™ HD Surgical System, da Vinci® Si™, da Vinci® Si-e™, EndoWrist®, Single-Site™, DVSTAT® and InSite® are trademarks or registered trademarks of Intuitive Surgical, Inc.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are necessarily estimates reflecting the best judgment of our management and involve a number of risks and uncertainties that could cause actual results to differ materially from those suggested by the forward-looking statements. Risks and uncertainties associated with adoption of Single Site Instrumentation for Cholecystectomy procedures is subject to patient demand and surgeon adoption which cannot be predicted; and, use of Single Site Instrumentation for procedures other than Cholecystectomy will be subject to our ability to obtain future FDA clearances. In addition, forward-looking statements should be considered in light of other various important factors, including, but not limited to: The impact of global and regional economic conditions and related credit markets and related impact on health care spending; health care reform legislation in the United States and its implications on hospital spending, reimbursement and fees which will be levied on certain medical device revenues; timing and success of product development and market acceptance of developed products; procedure counts; regulatory approvals, clearances and restrictions; guidelines and recommendations in the health care and patient communities; intellectual property positions and litigation; competition in the medical device industry and in the specific markets of surgery in which Intuitive Surgical operates; unanticipated manufacturing disruptions; delays in regulatory approvals of new manufacturing facilities or the inability to meet demand for products; and the results of the year-end audit and other risk factors under the heading “Risk Factors” in our report on Form 10-K for the year ended December 31, 2010, as updated from time to time by our quarterly reports on Form 10-Q and our other filings with the Securities and Exchange Commission. Statements concerning forecasts, revenue growth, procedure growth, future financial results, and statements using words such as “estimate,” “project,” “plan,” “intend,” “expect,” “anticipate,” “believe,” “targeted” and similar expressions are intended to identify forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. We undertake no obligation to publicly update or release any revisions to these forward-looking statements to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events.
While clinical studies support the effectiveness of the da Vinci Surgical System when used in minimally invasive surgery, individual results may vary. There are no guarantees of outcome. All surgeries involve the risk of major complications. Before you decide on surgery, discuss treatment options with your doctor. Understanding the risks of each treatment can help you make the best decision for your individual situation. Surgery with the da Vinci Surgical System may not be appropriate for every individual; it may not be applicable to your condition. Always ask your doctor about all treatment options, as well as their risks and benefits. Only your doctor can determine whether da Vinci Surgery is appropriate for your situation. The clinical information and opinions, including any inaccuracies expressed in this material by patients or doctors about da Vinci Surgery, are not necessarily those of Intuitive Surgical, Inc. and should not be considered as substitute for medical advice provided by your doctor. © 2011 Intuitive Surgical. All rights reserved. PN 875786 Rev A 12/11
CONTACT: Intuitive Surgical, Inc.
Investor Relations
408-523-2161
Intuitive Surgical, Inc.

Intuitive Surgical Announces New Single-Site(TM) Instrumentation for the da Vinci(R) Si(TM) Surgical SystemSUNNYVALE, Calif., Dec. 12, 2011 (GLOBE NEWSWIRE) — Intuitive Surgical, Inc. (Nasdaq:ISRG), the global leader in minimally invasive robotic-assisted surgery, today announced that it received FDA clearance to market its Single-Site Instrumentation for laparoscopic cholecystectomy procedures, the surgical removal of the gall bladder.
Single-Site Instrumentation provides da Vinci Si customers with a technology that enables cholecystectomy via a single incision, while providing the benefits of traditional multi-port da Vinci Surgery— enhanced surgical precision, control and stability and 3D HD visualization.
The Single-Site suite of instruments and accessories consists of the Single-Site Port, specialized curved cannulae and 5mm semi-rigid instruments, which are compatible with any da Vinci Si Surgical System. The design of the instruments and the da Vinci System’s Remote Center Technology are intended to reduce instrument crowding and external collisions typically associated with hand-held, laparoscopic single-incision devices.
Gary Guthart, CEO, Intuitive Surgical Inc., stated, “We are pleased with this clearance for our Single-Site instruments for use in laparoscopic cholecystectomy using the da Vinci System. We plan to immediately initiate a controlled rollout of these products in the US, while continuing our rollout in Europe. As we learn more about our customers’ needs within single-incision surgery, we anticipate future submissions to the US FDA and other global regulatory agencies related to expansion of the cleared indications for use, as well as additional Single-Site instruments.”
All da Vinci Si Surgical Systems are compatible with Single-Site™ Technology. The standard da Vinci and the da Vinci S Systems are not compatible with Single-Site Technology.
About Intuitive Surgical, Inc.
Intuitive Surgical, Inc. (Nasdaq:ISRG), headquartered in Sunnyvale, California, is the global technology leader in robotic-assisted, minimally invasive surgery (MIS). Intuitive Surgical develops, manufactures and markets robotic technologies designed to improve clinical outcomes and help patients return more quickly to active and productive lives. The company’s mission is to extend the benefits of minimally invasive surgery to the broadest possible base of patients. Intuitive Surgical — Taking surgery beyond the limits of the human hand.™
About the da Vinci Surgical System
The da Vinci Surgical System is a breakthrough surgical platform designed to enable complex surgery using a minimally invasive approach. The da Vinci Surgical System consists of an ergonomic surgeon console or consoles, a patient-side cart with three or four interactive robotic arms, a high-performance vision system and proprietary EndoWrist instruments. Powered by state-of-the-art robotic and computer technology, the da Vinci Surgical System is designed to scale, filter and seamlessly translate the surgeon’s hand movements into more precise movements of the EndoWrist instruments. The net result is an intuitive interface with breakthrough surgical capabilities. By providing surgeons with superior visualization, enhanced dexterity, greater precision and ergonomic comfort, the da Vinci Surgical System makes it possible for more surgeons to perform minimally invasive procedures involving complex dissection or reconstruction. This ultimately has the potential to raise the standard of care for complex surgeries, translating into numerous potential patient benefits, including less pain, a shorter recovery and quicker return to normal daily activities.
Intuitive®, Intuitive Surgical®, da Vinci®, da Vinci® S™, da Vinci® S™ HD Surgical System, da Vinci® Si™, da Vinci® Si-e™, EndoWrist®, Single-Site™, DVSTAT® and InSite® are trademarks or registered trademarks of Intuitive Surgical, Inc.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are necessarily estimates reflecting the best judgment of our management and involve a number of risks and uncertainties that could cause actual results to differ materially from those suggested by the forward-looking statements. Risks and uncertainties associated with adoption of Single Site Instrumentation for Cholecystectomy procedures is subject to patient demand and surgeon adoption which cannot be predicted; and, use of Single Site Instrumentation for procedures other than Cholecystectomy will be subject to our ability to obtain future FDA clearances. In addition, forward-looking statements should be considered in light of other various important factors, including, but not limited to: The impact of global and regional economic conditions and related credit markets and related impact on health care spending; health care reform legislation in the United States and its implications on hospital spending, reimbursement and fees which will be levied on certain medical device revenues; timing and success of product development and market acceptance of developed products; procedure counts; regulatory approvals, clearances and restrictions; guidelines and recommendations in the health care and patient communities; intellectual property positions and litigation; competition in the medical device industry and in the specific markets of surgery in which Intuitive Surgical operates; unanticipated manufacturing disruptions; delays in regulatory approvals of new manufacturing facilities or the inability to meet demand for products; and the results of the year-end audit and other risk factors under the heading “Risk Factors” in our report on Form 10-K for the year ended December 31, 2010, as updated from time to time by our quarterly reports on Form 10-Q and our other filings with the Securities and Exchange Commission. Statements concerning forecasts, revenue growth, procedure growth, future financial results, and statements using words such as “estimate,” “project,” “plan,” “intend,” “expect,” “anticipate,” “believe,” “targeted” and similar expressions are intended to identify forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. We undertake no obligation to publicly update or release any revisions to these forward-looking statements to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events.
While clinical studies support the effectiveness of the da Vinci Surgical System when used in minimally invasive surgery, individual results may vary. There are no guarantees of outcome. All surgeries involve the risk of major complications. Before you decide on surgery, discuss treatment options with your doctor. Understanding the risks of each treatment can help you make the best decision for your individual situation. Surgery with the da Vinci Surgical System may not be appropriate for every individual; it may not be applicable to your condition. Always ask your doctor about all treatment options, as well as their risks and benefits. Only your doctor can determine whether da Vinci Surgery is appropriate for your situation. The clinical information and opinions, including any inaccuracies expressed in this material by patients or doctors about da Vinci Surgery, are not necessarily those of Intuitive Surgical, Inc. and should not be considered as substitute for medical advice provided by your doctor. © 2011 Intuitive Surgical. All rights reserved. PN 875786 Rev A 12/11
CONTACT: Intuitive Surgical, Inc.         Investor Relations         408-523-2161Intuitive Surgical, Inc.

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How To Make Smart Phones Into Pathology Labs

How To Make  Smart Phones Into Pathology Labs

A biomolecular detection platform is presented that utilizes a capacitive touchscreen to measure DNA concentration. The technology is ready for integration into touchscreen-equipped smart phones or smart pads, and should truly accelerate the realization of personalized portable biosensors.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201105986/abstract

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Medical App to Treat Presbyopia a Non-Invasive Software Solution

Medical App to Treat Presbyopia a Non-Invasive Software Solution

Learn how you can remove your reading glasses in just 15 min training per day! This Medical app will cost about $95 and will become available early next year.

As people age, the lens loses its focusing power resulting in near vision deterioration. Unable to focus the way we used to, images sent to be processed in the brains’ visual cortex are unfocused and processing is slow and very difficult, resulting in a blurred image. This unavoidable deterioration of the eyes as we age can be compensated by boosting the speed and quality of image processing in the brain. Using advance, non-invasive methodologies researched over the last 15 years and successfully tested in numerous clinical trials, GlassesOff™ can help you achieve over 80% improvement in vision acuity!

GlassesOff™ is a non-invasive software solution that boosts the brain’s visual cortex performance. By boosting the brains image processing speed and contrast sensitivity, among others, users compensate for the biological deterioration of the eyes, thereby achieving an average improvement of 80% in visual acuity. This unique learning methodology by means of perceptual tasks encompasses parts of the learning process that are independent from conscious forms of learning and involve structural and/or functional changes in the visual cortex of the brain.

How it works?

Similar to computers binary code, everything captured by the human eye is translated into the equivalent of “0” and “1” by the vision system. Those “0” and “1” are translated into visual images such as Gabor patches that vary by their spatial frequency, contrast and spatial orientation and are best for stimulating the neurons in the early visual cortex of the brain. GlassesOff™ product enhances the visual system’s image processing capabilities by using the optimal Gabor patches to stimulate the visual cortex. GlassesOff™ treatment significantly boosts the speed and quality of image processing in the brain.

How long does the treatment take?

Just like any other product treating a medical condition, GlassesOff™ treatment duration and impact is affected by users’ initial presbyopic state and visual cortex learning capabilities. Our personalized treatments adjust itself on an ongoing basis to the user’s condition and progress to assure maximal improvement in minimal time. Still, on average, users that train3 times per week (each training session lasts around 15 min), complete the treatment within 3 months. Once eliminating the need for reading glasses, we recommend users to implement our maintenance training protocol, which only requires 2-3 treatment session per month.

How do I know if I fit the program?

Presbyopia (“Aging Eye”) affects most people over the age of 40 and nearly everyone by the age of 51. People suffering from Presbyopia usually experience some of the following symptoms: 1) blurred near-vision, 2) tired eyes or 3) headaches. If you suffer from any of these symptoms, you are advised to use GlassesOff™ treatment to correct your existing Presbyopia and prevent the expected natural deterioration. Furthermore, if you do not yet experience these symptoms but reaching the age of 40, you can use GlassesOff™ as a preventive treatment, precluding the expected Presbyopia from affecting your life.
Finally, before you start the training, we will provide you with a short online eye examination, which will determine whether the GlassesOff™ treatment will fit you.

What are the requirements?

GlassesOff™ product does not require any special equipment or special medical examinations. The product can run on most devices that use a display, to include: smart mobile phones (e.g. iPhone), PCs & tablet computes or even interactive TV. Furthermore, you are not required to go through any ophthalmologic examination prior to using the product.

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Transform iPhone into High-quality Medical Imaging Device

Transform iPhone into High-quality Medical Imaging Device

Researchers Transform iPhone into High-quality Medical Imaging Device

Advanced, life-saving capabilities become a simple add-on to handheld technology you already use

WASHINGTON, Oct. 3—In a feat of technology tweaking that would rival MacGyver, a team of researchers from the University of California, Davis has transformed everyday iPhones into medical-quality imaging and chemical detection devices. With materials that cost about as much as a typical app, the decked-out smartphones are able to use their heightened senses to perform detailed microscopy and spectroscopy.  The team will present their findings at the Optical Society’s (OSA) Annual Meeting, Frontiers in Optics (FiO) 2011, taking place in San Jose, Calif. Oct. 16-20.

The enhanced iPhones could help doctors and nurses diagnose blood diseases in developing nations where many hospitals and rural clinics have limited or no access to laboratory equipment. In addition to bringing new sensing capabilities where they are needed most, the modified phones are also able transmit the real-time data to colleagues around the globe for further analysis and diagnosis.

“Field workers could put a blood sample on a slide, take a picture, and send it to specialists to analyze,” says Sebastian Wachsmann-Hogiu, a physicist with UC Davis’ Department of Pathology and Laboratory Medicine and the Center for Biophotonics, Science and Technology, and lead author of the research to be presented at FiO.

Microscope Makeover

The group is not the first to build a smartphone microscope. “But we thought we could make something simpler and less expensive,” Wachsmann-Hogiu says.

His first attempt took simplicity too far. “We started with a drop of water on the camera’s lens,” he says. “The water formed a meniscus, and its curved surface acted like a magnifying lens. It worked fine, but the water evaporated too fast.”

Then the team turned to ball lenses. These are finely ground glass spheres that act as low-powered magnifying glasses. The team used a 1-millimeter-diameter ball lens that costs $30-40 USD in their prototype, but mass-produced lenses could be substituted to reduce the price.

To build the microscope’s lens, Kaiqin Chu, a post-doctoral researcher in optics, inserted a ball lens into a hole in a rubber sheet, then simply taped the sheet over the smartphone’s camera.

At 5x magnification, the ball lens is no more powerful than a child’s magnifying glass. Yet when paired with the camera of a smartphone, the microscope could resolve features on the order of 1.5 microns, small enough to identify different types of blood cells.

There are two reasons why such low magnification produces such high-resolution images. First, ball lenses excel at gathering light, which determines resolution. Second, the camera’s semiconductor sensor consists of millions of light-capturing cells. Each cell is only about 1.7 microns across. This is small enough to capture precisely the tiny high-resolution image that comes through the ball lens.

Ball lenses pose some unique problems. The curvature of their sphere bends light as it enters the ball, distorting the image, except for a very small spot in the center. The researchers used digital image processing software to correct for this distortion. They also used the software to stitch together overlapping photos of the tiny in-focus areas into a single image large enough for analysis.

Even though smartphone micrographs are not as sharp as those from laboratory microscopes, they are able to reveal important medical information, such as the reduced number and increased variation of cells in iron deficiency anemia, and the banana-shaped red blood cells characteristic of sickle cell anemia.

Wachsmann-Hogiu’s team is working with UC Davis Medical Center to validate the device and determine how to use it in the field. They may also add features, such as larger lenses to diagnose skin diseases and software to count and classify blood cells automatically in order to provide instant feedback and perhaps recognize a wider range of diseases.

Simple Spectrometer

When researchers need additional diagnostic tools, the microscope could be swapped for a simple spectrometer that also uses light collected by the iPhone’s camera.

Spectrometers smear out light from an object, separating it into its composite wavelengths in much the way a prism breaks up white light in the familiar colors of the rainbow. Since atoms and molecules absorb very specific wavelengths when exposed to light, it is possible to tease out the chemical signature of materials by studying their spectra.

Like the microscope, the iPhone’s spectrometer takes advantage of smartphone imaging capabilities. “We had worked with spectrometers for diagnostics, and didn’t think it would be too far a stretch,” Wachsmann-Hogiu says.

The spectrometer that the researchers added to the iPhone is easy to build. It starts with a short plastic tube covered at both ends with black electrical tape. Narrow slits cut into the tape allow only roughly parallel beams of light from the sample to enter and exit the tube. It is this grating that smears, or spreads, the light into a spectrum of colors that scientists can use like a fingerprint to identify various molecules.

“If you didn’t have the slits, light would come in from all different angles and you could never separate it properly,” explains Zachary Smith, an optics post-doctoral researcher in the lab.

Though the spectrometer is still in its early stages, the researchers believe it could measure the amount of oxygen in the blood and help diagnose chemical markers of disease.

Because smartphone instruments are powerful and cheap, Wachsmann-Hogiu believes schools could use them to enrich science classes. Spectrometers could help illustrate lessons about light and energy. Microscopes could unveil an invisible world of sugar crystals, pollen grains, and microscopic organisms.

By intelligently exploiting smartphone features, Wachsmann-Hogiu’s group promises to both save lives and illuminate science.

The presentation, “Microscopy and Spectroscopy on a Cell Phone,” by Kaiqin Chu, Zachary J. Smith, Alyssa R. Espenson, Denis Dwyre, Stephen Lane, Dennis Matthews, and Sebastian Wachsmann-Hogiu of the Center for Biophotonics, University of California, Davis, Medical Center, Sacramento, Calif. will take place Wednesday, Oct. 19 at 12 p.m. at the Fairmont San Jose Hotel.

EDITOR’S NOTE: High-resolution images of the iPhone and image samples taken with the device are available upon request (see gallery below). Please contact Angela Stark, astark@osa.org.

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Download Free Medical Mobile Application for drug, disease, and diagnostic worth $159

Download Free Medical Mobile Application for drug, disease, and diagnostic worth $159

We are giving you Epocrates Essentials* ($159 value) for FREE. Our most popular premium mobile application offers the drug, disease, and diagnostic tools you need at the point-of-care. It’s free for the first 2 weeks of August only.

*Epocrates Essentials is compatible with iPhone/iPod touch, Google Android™, BlackBerry®, Palm OS® and Windows Mobile® platforms.

PLEASE NOTE: Medical students who activate the free Epocrates Essentials code must be attending an accredited United States medical school. Epocrates reserves the right to request a valid form of student identification for additional proof of enrollment. Any inaccuracies or misrepresentations regarding medical student status may result in penalties, including but not limited to, immediate termination of the Epocrates Essentials subscription.
Act fast and tell your friends!

http://www.epocrates.com/ma/FreeforMedicalStudents2011/

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Download Medical iPad App for Diagnostic Imaging

Download Medical iPad App for Diagnostic Imaging

Diagnostic Imaging Pathways is a clinical decision support tool and educational resource for diagnostic imaging. Developed with the input of clinicians and radiologists, the evidence-based pathways have been used by clinicians and educators world-wide.

The University of Western Australia’s Centre for Software Practice (CSP) has released a new iPad application which helps clinicians to choose the most appropriate diagnostic imaging examinations in a wide range of clinical scenarios.

The latest diagnostic education and decision support tool has been developed by CSP in collaboration with the Department of Imaging Services at the Royal Perth Hospital.

Diagnostic Imaging Pathways includes more than 130 pathways covering all the major organ systems and common clinical scenarios. The pathways have been developed based on broad clinical consensus, and best-available evidence, and are under continuous review and development.

The principle clinical lead behind the Diagnostic Imaging Pathways, Professor Richard Mendelson, said the application will help doctors make the right decisions delivering the right treatment at the right place and the right time.

“Thirty per cent of imaging requests are incorrect or inappropriate – the iPad application DiPHD will help make sure that patients have the best chance of getting the most accurate diagnosis,” Professor Mendelson said.

CSP Director Associate Professor David Glance said having the pathways available on a platform like the iPad ensures that doctors will be able to access vital information, literally at their fingertips.

“Imaging is the first step in future pathways that will also involve pathology and clinical referral guidelines,” Associate Professor Glance said.

DiPHD follows on from other award winning applications developed at the UWA CSP including MMEx, an eHealth platform used by clinicians throughout WA, Australia and New Zealand.

The application follows on from the success of the Diagnostic Imaging Pathways website.

Media references

Assoc Prof David Glance (UWA Centre for Software Practice)  (+61 4) 08 9165 79 begin_of_the_skype_highlighting              (+61 4) 08 9165 79      end_of_the_skype_highlighting
Dr Phillip Bairstow (Royal Perth Hospital)  (+61 8) 9224 1398 begin_of_the_skype_highlighting              (+61 8) 9224 1398      end_of_the_skype_highlighting
Aleta Johnston (UWA Public Affairs)  (+61 8) 6488 7977 begin_of_the_skype_highlighting              (+61 8) 6488 7977      end_of_the_skype_highlighting / (+61 4) 31 514 677 begin_of_the_skype_highlighting              (+61 4) 31 514 677      end_of_the_skype_highlighting

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Nanosensor “Tattoo” and a Modified iPhone Tracks Sodium and Glucose Level

Nanosensor “Tattoo” and a Modified iPhone Tracks Sodium and Glucose Level

Using a nanosensor “tattoo” and a modified iPhone, cyclists could closely monitor sodium levels to prevent dehydration, and anemic patients could track their blood oxygen levels.

Heather Clark, a professor in the Department of Pharmaceutical Sciences at Northeastern University, is leading a team working to make this possible. The team begins by injecting a solution containing carefully chosen nanoparticles into the skin. This leaves no visible mark, but the nanoparticles will fluoresce when exposed to a target molecule, such as sodium or glucose. A modified iPhone then tracks changes in the level of fluorescence, which indicates the amount of sodium or glucose present. Clark presented this work at the BioMethods Boston conference at Harvard Medical School last week.

The tattoos were originally designed as a way around the finger-prick bloodletting that is the standard technique for measuring glucose levels in those with diabetes. But Clark says they could be used to track many things besides glucose and sodium, offering a simpler, less painful, and more accurate way for many people to track many important biomarkers.

“I don’t think there’s any doubt that this sort of technology will catch on,” says Jim Burns, head of drug and biomedical research and development at Genzyme.

The tattoo developed by Clark’s team contains 120-nanometer-wide polymer nanodroplets consisting of a fluorescent dye, specialized sensor molecules designed to bind to specific chemicals, and a charge-neutralizing molecule.

Once in the skin, the sensor molecules attract their target because they have the opposite charge. Once the target chemical is taken up, the sensor is forced to release ions in order to maintain an overall neutral charge, and this changes the fluorescence of the tattoo when it is hit by light. The more target molecules there are in the patient’s body, the more the molecules will bind to the sensors, and the more the fluorescence changes.

The original reader was a large boxlike device. One of Clark’s graduate students, Matt Dubach, improved upon that by making a modified iPhone case that allows any iPhone to read the tattoos.

Here’s how it works: a case that slips over the iPhone contains a nine-volt battery, a filter that fits over the iPhone’s camera, and an array of three LEDs that produce light in the visible part of the spectrum. This light causes the tattoos to fluoresce. A light-filtering lens is then placed over the iPhone’s camera. This filters out the light released by the LEDs, but not the light emitted by the tattoo. The device is pressed to the skin to prevent outside light from interfering.

Dubach and Clark hope to create an iPhone app that would easily measure and record sodium levels. At the moment, the iPhone simply takes images of the fluorescence, which the researchers then export to a computer for analysis. They also hope to get the reader to draw power from the iPhone itself, rather than from a battery.

Clark is working to expand her technology from glucose and sodium to include a wide range of potential targets. “Let’s say you have medication with a very narrow therapeutic range,” she says. Today, “you have to try it [a dosage] and see what happens.” She says her nanosensors, in contrast, could let people monitor the level of a given drug in their blood in real time, allowing for much more accurate dosing.

The researchers hope to soon be able to measure dissolved gases, such as nitrogen and oxygen, in the blood as a way of checking respiration and lung function. The more things they can track, the more applications will emerge, says Clark.

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