Archive for ‘Imaging’

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Global Electroencephalogram Equipment Market by Manufacturers, Regions, Type and Application, Forecast to 2021

The Global Electroencephalogram Equipment Market research study report is a respected source of information which offers a telescopic view of the current market status. Various key factors are discussed in the report, which will help the buyer in studying the Global Electroencephalogram Equipment market trends and opportunities. The Global Electroencephalogram Equipment market is a highly diligent study on competitive landscape analysis, prime manufacturers, marketing strategies analysis, Market Effect Factor Analysis and Consumer Needs by major regions, types, applications in Global market considering the past, current and future state of the Global Electroencephalogram Equipment industry. The report provides a thorough overview of the Global Electroencephalogram Equipment Market including definitions, classifications, applications and chain structure.

This Research study focus on these types: –

  • Routine EEG
  • Sleep EEG
  • Ambulatory EEG
  • Other

This Research study focus on these applications: –

  • Hospital
  • Clinic
  • Other

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This report studies Interferons in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with Production, price, revenue and market share for each manufacturer, covering

  • Natus Medical Incorporated
  • Nihon Kohden America
  • Cadwell Laboratories
  • Electrical Geodesics Incorporated
  • Covidien llc
  • Micromed
  • Neuroelectrics
  • EB NEURO
  • SYMTOP
  • NCC
  • Shanghai Medical Instruments

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Several important areas are covered in this Global Electroencephalogram Equipment market research report. Some key points among them: –

  1. What Overview Global Electroencephalogram Equipment Says? This Overview Includes Diligent Analysis of Scope, Types, Application, Sales by region, manufacturers, types and applications
  2. What Is Global Electroencephalogram Equipment Competition considering Manufacturers, Types and Application? Based on Thorough Research of Key Factors
  3. Who Are Global Electroencephalogram Equipment Global Key Manufacturers? Along with this survey you also get their Product Information (Type, Application and Specification)
  4. Global Electroencephalogram Equipment’s Manufacturing Cost Analysis –This Analysis is done by considering these prime elements like Key RAW Materials, Price Trends, Market Concentration Rate of Raw Materials, Proportion of Raw Materials and Labour Cost in Manufacturing Cost Structure
  5. Global Electroencephalogram Equipment Industrial Chain Analysis
  6. Global Electroencephalogram Equipment Marketing strategies analysis by
  7. Market Positioning
  8. Pricing and Branding Strategy
  9. Client Targeting
  10. Global Electroencephalogram Equipment Effect Factor Analysis
  11. Technology Process/Risk Considering Substitute Threat and Technology Progress In Global Electroencephalogram Equipment Industry
  12. Consumer Needs or What Change Is Observed in Preference of Customer
  13. Political/Economical Change
  14. What is Global Electroencephalogram Equipment forecast (2016-2021) Considering Sales, Revenue for Regions, Types and Applications?

Topics such as sales and sales revenue overview, production market share by product type, capacity and production overview, import, export, and consumption are covered under the development trend section of the Global Electroencephalogram Equipment market report.

Lastly, the feasibility analysis of new project investment is done in the report, which consist of a detailed SWOT analysis of the Global Electroencephalogram Equipment market. Both established and new players in the Global Electroencephalogram Equipment industry can use this report for complete understanding of the market.

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Some of key Tables and Figures included in this research study: –

  1. Figure Picture of Global Electroencephalogram Equipment
  2. Figure USA, Europe, China. Southeast Asia, India, Japan Global Electroencephalogram Equipment Revenue and Growth Rate (2011-2021)
  3. Table Production Base and Market Concentration Rate of Raw Material
  4. Figure Manufacturing Cost Structure of Global Electroencephalogram Equipment
  5. Figure Manufacturing Process Analysis of Global Electroencephalogram Equipment
  6. Figure Global Electroencephalogram Equipment Industrial Chain Analysis
  7. Figure Global Electroencephalogram Equipment Sales and Growth Rate Forecast (2016-2021)
  8. Figure Global Electroencephalogram Equipment Revenue and Growth Rate Forecast (2016-2021)
  9. Table Global Electroencephalogram Equipment Sales Forecast by Regions (2016-2021)
  10. Table Global Electroencephalogram Equipment Sales Forecast by Type (2016-2021)
  11. Table Global Electroencephalogram Equipment Sales Forecast by Application (2016-2021)

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Flexible Patch with Stainless Steel Microneedles for Safe and Painless Delivery of Drugs

Flexible Patch with Stainless Steel Microneedles for Safe and Painless Delivery of Drugs

patch-patch

 

Scientists at the KTH Royal Institute of Technology in Stockholm, Sweden have developed a new flexible microneedle patch that resolves some of the limitations of similar existing devices. Typically, drug delivery patches designed to penetrate only the top layers of skin, as opposed to transdermal devices, are made of a single material. While it’s best to have the base rather soft to achieve optimal contact and comfort, the needles have to be rigid in order to successfully pierce the skin.

flexible-patchThe KTH  team developed a composite device that consists of a soft base made from a polymer and rigid stainless needles that penetrate the skin. “To the best of our knowledge, flexible and stretchable patches with arrays of sharp and stiff microneedles have not been demonstrated to date,” said Frank Niklaus, a professor of micro and nanofabrication at KTH, in a statement.

The team built two versions of their patch, one more flexible than the other. The more stretchable device showed excellent pliability and each of its 50 needles successfully penetrated the skin in a 30 minute test.

If the technology proves itself in additional studies, it may help make microneedle patches considerably more common and applicable to a variety of patients and conditions.

Study in PLOS ONEFlexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing…

Via: KTH Royal Institute of Technology…

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Dermatophytic Onychomycosis Market to Reach US$ 4,706.3 Mn by the end of 2021

Dermatophytic Onychomycosis Market to Reach US$ 4,706.3 Mn by the end of 2021

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The global dermatophytic onychomycosis therapeutics market is anticipated to expand at a healthy CAGR during the forecast period. By product type, the market is segmented into Nail paint and tablet, which is again sub-divided into prescription (Rx) and over-the-counter (OTC) sub segments. The nail paint segment is expected to contribute a maximum share to the global dermatophytic onychomycosis therapeutics market and expand at the fastest CAGR of 8.3% during the forecast period. By treatment, the market is segmented into topical and oral therapy. Among these, the topical segment is anticipated to be dominant throughout the forecast period and projected to account for about 70% share of the total global dermatophytic onychomycosis market revenue by 2021. By distribution channels, the market is segmented into hospitals, dermatology and podiatry clinics, independent pharmacies, mail order pharmacies, and drug stores. Among these, drug stores are estimated to be largest segment with 47% share of the total global market revenue by 2015 end. The drug stores segment is expected to register the fastest CAGR during the forecast period. Independent pharmacies are projected to be the second most attractive segment of the global dermatophytic onychomycosis therapeutics market by 2015 end.

Market growth is primarily driven by factors such as increase in the prevalence of fungal toe nail infections in the U.S. and Canada, and rising per capita healthcare expenditure across the globe. Easy application of nail paints is also expected to drive demand for dermatophytic onychomycosis drugs. However, adverse effects associated with anti-fungal drugs and lack of awareness about dermatophytic onychomycosis in Asia Pacific, Middle East and Africa, and Latin America are expected to impede growth of the global dermatophytic onychomycosis therapeutics market.

This report covers global and regional trends along with an analysis of the market potential. North America is expected to account for over 43% revenue share of the total dermatophytic onychomycosis therapeutics market by 2015 end i.e. holding the maximum market share. Whereas Europe is projected to grow at a healthy CAGR of 7.3% due to increasing awareness about fungal nail infections.

Global dermatophytic onychomycosis therapeutics market report begins with an overview of the global market in terms of value. This section includes detailed analysis of key trends, drivers and restraints, and opportunities. All of these are factors that impact market growth. Impact analysis of key growth drivers and restraints based on the weighted average of each one of these factors in a model-based approach is included in the market report to better equip clients with crystal clear decision-making insights.

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Key players of the global dermatophytic onychomycosis therapeutics market include Galderma S.A., Valeant Pharmaceuticals International Inc., Novartis AG, Pfizer Inc., Janssen Pharmaceuticals, and others. Leading companies in this market collaborate with healthcare solutions and services providers in order to advance operational efficiencies and provide improved patient care.

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Latest Research: 2016-2020 Plasmapheresis Market Global Report

Latest Research: 2016-2020 Plasmapheresis Market Global Report

logo-orbis506

 

2016 Global Plasmapheresis Industry Report is a professional and in-depth research report on the world’s major regional market conditions of the Plasmapheresis industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China).

Place a direct purchase order on this report @http://www.orbisresearch.com/contact/purchase/114517 .

The report firstly introduced the Plasmapheresis basics: definitions, classifications, applications and industry chain overview; industry policies and plans; product specifications; manufacturing processes; cost structures and so on. Then it analyzed the world’s main region market conditions, including the product price, profit, capacity, production, capacity utilization, supply, demand and industry growth rate etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

Request a sample @ http://www.orbisresearch.com/contacts/request-sample/114517 .

The report includes six parts, dealing with: 1.) basic information; 2.) the Asia Plasmapheresis industry; 3.) the North American Plasmapheresis industry; 4.) the European Plasmapheresis industry; 5.) market entry and investment feasibility; and 6.) the report conclusion.

Some points from Table of Contents:
Part I Plasmapheresis Industry Overview
Chapter One Plasmapheresis Industry Overview
Chapter Two Plasmapheresis Up and Down Stream Industry Analysis
Part II Asia Plasmapheresis Industry (The Report Company Including the Below Listed But Not All)
Chapter Three Asia Plasmapheresis Market Analysis
Chapter Four 2011-2016 Asia Plasmapheresis Productions Supply Sales Demand Market Status and Forecast
Chapter Five Asia Plasmapheresis Key Manufacturers Analysis
Chapter Six Asia Plasmapheresis Industry Development Trend
Part III North American Plasmapheresis Industry (The Report Company Including the Below Listed But Not All)
Chapter Seven North American Plasmapheresis Market Analysis
Chapter Eight 2011-2016 North American Plasmapheresis Productions Supply Sales Demand Market Status and Forecast
Chapter Nine North American Plasmapheresis Key Manufacturers Analysis
Chapter Ten North American Plasmapheresis Industry Development Trend
Part IV Europe Plasmapheresis Industry Analysis (The Report Company Including the Below Listed But Not All)
Chapter Eleven Europe Plasmapheresis Market Analysis
Chapter Twelve 2011-2016 Europe Plasmapheresis Productions Supply Sales Demand Market Status and ForecastChapter Thirteen Europe Plasmapheresis Key Manufacturers Analysis
Chapter Thirteen Europe Plasmapheresis Key Manufacturers Analysis
Chapter Fourteen Europe Plasmapheresis Industry Development Trend
Part V Plasmapheresis Marketing Channels and Investment Feasibility
Chapter Fifteen Plasmapheresis Marketing Channels Development Proposals Analysis
Chapter Sixteen Development Environmental Analysis
Chapter Seventeen Plasmapheresis New Project Investment Feasibility Analysis
Part VI Global Plasmapheresis Industry Conclusions
Chapter Eighteen 2011-2016 Global Plasmapheresis Productions Supply Sales Demand Market Status and Forecast
Chapter Nineteen Global Plasmapheresis Industry Development Trend
Chapter Twenty Global Plasmapheresis Industry Research Conclusions

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Horus Recognizes Faces, Reads Text, Describes World Around for Blind People

Horus Recognizes Faces, Reads Text, Describes World Around for Blind People

horus

 

horus-2

 

A new device is expected to soon be made available for visually impaired people that uses voice to describe the world in front of them. The Horus is essentially a headset with a 3D forward facing camera and a small computer that it’s connected to. The computer constantly runs a computer vision algorithm that recognizes objects and places in front of the user. Once identified, the system reads aloud what it’s seeing.

The system also spots obstacles, thanks to its 3D vision, and warns wearers using various tones. It can read text placed in front of it as well, and it can even tell faces apart. The user can essentially save images of faces of friends and relatives within the Horus, so that when a familiar person comes within view the device lets the user know.

The Horus is not yet available, but Eyra LTD, the company behind the device, has a waiting list for early access.

Check out this video that shows off how the system works:

Info page: Horus…

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Global Patient Fluid Status Monitor Device Market By Key Vendors, Market Drivers, Challenges, Share,Trends & Forecasts 2021

Global Patient Fluid Status Monitor Device Market By Key Vendors, Market Drivers, Challenges, Share,Trends & Forecasts 2021

WiseGuy-Reports82

 

“Patient fluid status monitor device generally refers to device used clinically to measures hydration in a patient, to determine whether or not the patient is dehydrated or retaining fluids. By quantifying fluid volume status, clinicians can optimize medical regimens and hydration critical in the management of heart failure patients; besides, patient fluid status monitor device can also be used in the treatment of hypertension patients and ESRD patients.

Currently, there are patient fluid status monitor device produced by two manufacturers available in the market, which include Medtronic and NMT (Noninvasive Medical Technologies). Besides, another company, Sensible Medical had launched a new type of patient fluid status monitor device called SensiVest?.”

Scope of the Report:
This report focuses on the Patient Fluid Status Monitor Device in Global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

Market Segment by Manufacturers, this report covers
Noninvasive Medical Technologies
Medtronic
Sensible Medical

 

Complete Report Details @ https://www.wiseguyreports.com/reports/809448-global-patient-fluid-status-forecast-to-2021

 

Market Segment by Regions, regional analysis covers
North America (USA, Canada and Mexico)
Europe (Germany, France, UK, Russia and Italy)
Asia-Pacific (China, Japan, Korea, India and Southeast Asia)
South America, Middle East and Africa

Market Segment by Type, covers
Invasive
Non-invasive

Market Segment by Applications, can be divided into
Heart Failure Treatment
Other Disease Treatment

 

Table of Contents

Global Patient Fluid Status Monitor Device Market by Manufacturers, Regions, Type and Application, Forecast to 2021 

1 Market Overview
1.1 Patient Fluid Status Monitor Device Introduction
1.2 Market Analysis by Type
1.2.1 Invasive
1.2.2 Non-invasive
1.2.3
1.3 Market Analysis by Applications
1.3.1 Heart Failure Treatment
1.3.2 Other Disease Treatment
1.3.3
1.4 Market Analysis by Regions
1.4.1 North America (USA, Canada and Mexico)
1.4.1.1 USA
1.4.1.2 Canada
1.4.1.3 Mexico
1.4.2 Europe (Germany, France, UK, Russia and Italy)
1.4.2.1 Germany
1.4.2.2 France
1.4.2.3 UK
1.4.2.4 Russia
1.4.2.5 Italy
1.4.3 Asia-Pacific (China, Japan, Korea, India and Southeast Asia)
1.4.3.1 China
1.4.3.2 Japan
1.4.3.3 Korea
1.4.3.4 India
1.4.3.5 Southeast Asia
1.4.4 South America, Middle East and Africa
1.4.4.1 Brazil
1.4.4.2 Egypt
1.4.4.3 Saudi Arabia
1.4.4.4 South Africa
1.4.4.5 Nigeria
1.5 Market Dynamics
1.5.1 Market Opportunities
1.5.2 Market Risk
1.5.3 Market Driving Force

2 Manufacturers Profiles
2.1 Noninvasive Medical Technologies
2.1.1 Business Overview
2.1.2 Patient Fluid Status Monitor Device Type and Applications
2.1.2.1 Type 1
2.1.2.2 Type 2
2.1.3 Noninvasive Medical Technologies Patient Fluid Status Monitor Device Sales, Price, Revenue, Gross Margin and Market Share
2.2 Medtronic
2.2.1 Business Overview
2.2.2 Patient Fluid Status Monitor Device Type and Applications
2.2.2.1 Type 1
2.2.2.2 Type 2
2.2.3 Medtronic Patient Fluid Status Monitor Device Sales, Price, Revenue, Gross Margin and Market Share
2.3 Sensible Medical
2.3.1 Business Overview
2.3.2 Patient Fluid Status Monitor Device Type and Applications
2.3.2.1 Type 1
2.3.2.2 Type 2
2.3.3 Sensible Medical Patient Fluid Status Monitor Device Sales, Price, Revenue, Gross Margin and Market Share

…………

3 Global Patient Fluid Status Monitor Device Market Competition, by Manufacturer
3.1 Global Patient Fluid Status Monitor Device Sales and Market Share by Manufacturer
3.2 Global Patient Fluid Status Monitor Device Revenue and Market Share by Manufacturer
3.3 Market Concentration Rate
3.3.1 Top 3 Patient Fluid Status Monitor Device Manufacturer Market Share
3.3.2 Top 6 Patient Fluid Status Monitor Device Manufacturer Market Share
3.4 Market Competition Trend

4 Global Patient Fluid Status Monitor Device Market Analysis by Regions
4.1 Global Patient Fluid Status Monitor Device Sales, Revenue and Market Share by Regions
4.1.1 Global Patient Fluid Status Monitor Device Sales by Regions (2011-2016)
4.1.2 Global Patient Fluid Status Monitor Device Revenue by Regions (2011-2016)
4.2 North America Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
4.3 Europe Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
4.4 Asia-Pacific Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
4.5 South America Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
4.6 Middle East and Africa Patient Fluid Status Monitor Device Sales and Growth (2011-2016)

5 North America Patient Fluid Status Monitor Device by Countries
5.1 North America Patient Fluid Status Monitor Device Sales, Revenue and Market Share by Countries
5.1.1 North America Patient Fluid Status Monitor Device Sales by Countries (2011-2016)
5.1.2 North America Patient Fluid Status Monitor Device Revenue by Countries (2011-2016)
5.2 USA Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
5.3 Canada Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
5.4 Mexico Patient Fluid Status Monitor Device Sales and Growth (2011-2016)

6 Europe Patient Fluid Status Monitor Device by Countries
6.1 Europe Patient Fluid Status Monitor Device Sales, Revenue and Market Share by Countries
6.1.1 Europe Patient Fluid Status Monitor Device Sales by Countries (2011-2016)
6.1.2 Europe Patient Fluid Status Monitor Device Revenue by Countries (2011-2016)
6.2 Germany Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
6.3 UK Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
6.4 France Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
6.5 Russia Patient Fluid Status Monitor Device Sales and Growth (2011-2016)
6.6 Italy Patient Fluid Status Monitor Device Sales and Growth (2011-2016)

....Continued

 

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GE Unveils Virtually Silent MRI Technology at RSNA

GE Unveils Virtually Silent MRI Technology at RSNA

GE Unveils Virtually Silent MRI Technology at RSNA

Today at RSNA 2012, GE Healthcare (NYSE: GE) introduced the 510(k) pending Silent Scan*, a revolutionary technology designed to address one of the most significant impediments to patient comfort – excessive acoustic noise generated during an MR scan. Conventional MR scanners can generate noise in excess of 110 dBA (decibels) levels, roughly equivalent to rock concerts and requires ear protection. GE’s exclusive Silent Scan technology is designed to reduce MR scanner noise to near ambient (background) sound levels and thus can improve a patient’s MR exam experience.

“Silent Scan is a huge breakthrough for the MR industry and for patients around the world,” says Richard Hausmann, president and CEO, GE Healthcare MR. “Excessive acoustic noise is a major cause of patient discomfort during MR scans and GE is addressing that with Silent Scan, a new MR advanced application and a major innovation in the healthcare industry. GE is very serious about Humanizing MR and making its MR systems patient-friendly, safe, and without compromise.”

Historically, acoustic noise mitigation techniques have focused on insulating components and muffling sound as opposed to treating the noise at the source. With Silent Scan, acoustic noise is essentially eliminated by employing a new advanced 3D acquisition and reconstruction technique called Silenz, in combination with GE Healthcare’s proprietary design of the high-fidelity MR gradient and RF system electronics. Silent Scan is designed to eliminate the noise at its source; with Silent Scan, patients will experience a more relaxing scanning environment.

Silent Scan is one way in which GE MR is Humanizing MR and putting patients first. GE’s MR systems deliver superb image quality and an optimized patient experience, balancing caring design with insightful technology. Another example of this on display at RSNA is the Optima MR430s 1.5T extremity scanner, which allows patients to undergo an MR exam while sitting in a chair, with Image Quality equivalent to a traditional whole body MR system.

*Silent Scan is 510(k) pending at U.S. FDA and not available for sale.

GE Healthcare at RSNA 2012

Each year in Chicago, the conference of the Radiological Association of North America (RSNA) provides a forum for showcasing the latest innovations in medical imaging. If you are attending the conference, please visit GE Healthcare at booth number 5433 in McCormick Place south hall. Throughout the week of the event, GE Healthcare will distribute news and information using these digital platforms:

· Digital press kit: newsroom.gehealthcare.com/press-kits/ge-healthcare-at-rsna-2012

· Twitter: @GEHealthcare and hashtag #GEWorks

· YouTube channel: www.youtube.com/gehealthcare

· Flickr: www.flickr.com/people/gehealthcare

· Instagram: instagram.com/generalelectric

###

About GE Healthcare

GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our broad expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, drug discovery, biopharmaceutical manufacturing technologies, performance improvement and performance solutions services help our customers to deliver better care to more people around the world at a lower cost. In addition, we partner with healthcare leaders, striving to leverage the global policy change necessary to implement a successful shift to sustainable healthcare systems.

Our “healthymagination” vision for the future invites the world to join us on our journey as we continuously develop innovations focused on increasing access and improving quality and affordability around the world. Headquartered in the United Kingdom, GE Healthcare is a unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employees are committed to serving healthcare professionals and their patients in more than 100 countries. For more information about GE Healthcare, visit our website at www.gehealthcare.com. For our latest news, please visit http://newsroom.gehealthcare.com.

At RSNA, GE Healthcare was showcasing an impressive new MRI technology called Silent Scan, which might make undergoing an MRI scan much more comfortable than it is today. If you have ever had an MRI exam, you know that conventional MR scanners can be very loud. While scanning they typically produce sound levels of 90-110 decibels, which contributes to the already not-so-pleasant experience of the patient.

GE’s new Silent Scan technology reduces MR scanner noise to near ambient sound levels through new developments in both hardware and software. It uses a new advanced 3D acquisition and reconstruction technique called Silenz, in combination with high-fidelity MR gradient and RF system electronics. The company demonstrated this in action through a live-video link with their headquarters in Milwaukee where they showed an MRI scanning with Silent Scan, and indeed the noise during scanning was barely perceptible.

According to a representative at RSNA, for now the technique is limited to T1 and PD-weighted scans at 1.5 Tesla, but development is underway to make it work with other types of sequences and 3 Tesla systems. The rep was very tight-lipped about the exact techniques GE is using, as some of them are still in the process of being patented. After it receives FDA clearance, Silent Scan will both be available on new scanners as well as as an upgrade on some of GE’s most recent systems.

Source : http://www.genewscenter.com/Content/Detail.aspx?ReleaseID=15491&NewsAreaID=2

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Misfit Wearables Announces Shine, a Shiny New Wireless Fitness Tracker

Misfit Wearables Announces Shine, a Shiny New Wireless Fitness Tracker

Misfit Wearables Announces Shine, a Shiny New Wireless Fitness Tracker

Misfit Wearables (Redwood City, California) has announced their first product, a wireless fitness tracker called the Shine. But don’t let the company’s name fool you. The Shine is a tiny, all-metal disc dotted with a halo of invisible status lights that can probably fit in with any style of clothing you’re wearing (or any Apple product, at least). Measuring a bit larger than a U.S. quarter coin and weighing slightly less than two of them, the Shine is forged from a single piece of super strong aircraft-grade aluminum.

Misfit Shine 2 Misfit Wearables Announces Shine, a Shiny New Wireless Fitness Tracker (VIDEO)The insides aren’t too shabby either. The Shine uses proprietary algorithms to track your steps, bike pedals, and swim strokes (Yes, it’s waterproof!). You check your progress by simply tapping on the Shine, activating the halo of lights that instantly shows you how close you are to reaching your daily fitness goal. Power is provided through a coin cell battery, which Misfit claims will last about six months. Unsurprisingly, the Shine will sync to an iOS app on almost any iOS device, but very interestingly, syncing uses a special technology that doesn’t involve cables, docking stations, or even wireless pairing; all you need to do is place the Shine on your device’s screen (we’re looking into how that actually works).

When the Shine launches in spring 2013, it’ll retail for $99. It comes with a clasp to clip it on your pants, bra, shirt, or shoes, or you can also purchase a sports ($19) or leather ($49) band if you want to wear it around your wrist. Want to get your hands on the Shine a whole month before it hits retail stores in April 2013? You can head over to Misfit’s website and support the Shine through Indiegogo.

Source : http://www.misfitwearables.com/shine

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Filming The Immune System in Action

Filming The Immune System in Action

Filming The Immune System in Action

Forget what’s number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology.

For the first time in Australia, scientists at Sydney’s Centenary Institute have filmed an immune cell becoming infected by a parasite and followed the infection as it begins to spread throughout the body.

Professor Wolfgang Weninger, head of the Immune Imaging program at the Centenary Institute, says the discovery (published in PLoS Pathogens) was made possible using high powered multi-photon microscopy which allows real cells to be viewed in real time.

“Using multi-photon microscopy, we studied dendritic cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they were very active, moving around as though seeking out pathogens,” explains Professor Weninger. “Once we established this, it was fascinating to introduce the Leishmania infection and watch as the parasite was picked up by the cells and the process by which it began to spread throughout the body.”

Leishmaniasis affects up to 12 million people in parts of Africa, the Middle East and South America. The disease causes skin sores and can affect internal organs such as the spleen, liver and bone marrow. If left untreated, it can be fatal.

The ability to visually follow a pathogen on its journey through the immune cells provides critical insight for future vaccine design and has potential to improve current vaccinations.

“We now have a general idea of how pathogens are recognised by the immune system and which cells are involved,” Professor Weninger says. “This means we can look at identifying the molecules responsible for the uptake of Leishmania infection and these molecules could become vaccine targets. Additionally, we can investigate the immune responses of other infections which could lead to better vaccines.”

“On the other side of the story, scientists can now visualise the pathway of current vaccines in the immune system, providing greater understanding and the potential for refining current interventions against disease.”

Centenary Institute Executive Director, Professor Mathew Vadas, says the multi-photon microscope used to film this immune process is the Hubble telescope of medical research.

“The Hubble allowed the universe to be seen with absolute clarity, which wasn’t before possible from earth,” he explains. “This is exactly the same as multi-photon microscopy – it provides a unique and innovative view of cells, unveiling a whole new understanding of how immune processes work.”

Dendritic cells (DC), including those of the skin, act as sentinels for intruding microorganisms. In the epidermis, DC (termed Langerhans cells, LC) are sessile and screen their microenvironment through occasional movements of their dendrites. The spatio-temporal orchestration of antigen encounter by dermal DC (DDC) is not known. Since these cells are thought to be instrumental in the initiation of immune responses during infection, we investigated their behavior directly within their natural microenvironment using intravital two-photon microscopy. Surprisingly, we found that, under homeostatic conditions, DDC were highly motile, continuously crawling through the interstitial space in a G?i protein-coupled receptor–dependent manner. However, within minutes after intradermal delivery of the protozoan parasite Leishmania major, DDC became immobile and incorporated multiple parasites into cytosolic vacuoles. Parasite uptake occurred through the extension of long, highly dynamic pseudopods capable of tracking and engulfing parasites. This was then followed by rapid dendrite retraction towards the cell body. DDC were proficient at discriminating between parasites and inert particles, and parasite uptake was independent of the presence of neutrophils. Together, our study has visualized the dynamics and microenvironmental context of parasite encounter by an innate immune cell subset during the initiation of the immune response. Our results uncover a unique migratory tissue surveillance program of DDC that ensures the rapid detection of pathogens.

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Cutaneous Leishmaniasis is a difficult-to-treat disease affecting millions of people worldwide. Hence, there is high demand for the development of vaccines against Leishmania parasites, begging for a better understanding of immune responses against this pathogen. Dendritic cells, as part of the innate immune system, are thought to act as gatekeepers against intruding pathogens. However, their behavior in the context of intact tissues is incompletely understood. Here, we have used intravital two-photon microscopy to visualize the behavior of skin resident dendritic cells in real time, both in the steady-state and upon parasite encounter. We have found that migratory dermal dendritic cells are capable of rapidly sensing Leishmania parasites injected into the skin. This occurred through the formation of highly motile cellular processes capable of engulfing parasites, followed by parasite uptake into the cell. Together, our study provides a new vista of the orchestration of host cell–pathogen encounter in the three-dimensional context of intact tissues. Our results serve as the basis for a better understanding of the dynamic regulation of tissue surveillance by dendritic cells.

Australian scientists from the Centenary Institute have filmed how a parasite infects an immune cell, and then followed the process of the pathogen spreading further into the body.

Professor Wolfgang Weninger, head of the Immune Imaging program at the Centenary Institute, says the discovery (published in PLoS Pathogens) was made possible using high powered multi-photon microscopy which allows real cells to be viewed in real time.

“Using multi-photon microscopy, we studied dendritic cells in the skin. Under normal conditions we found the cells in the epidermis (top layer) were static, whereas in the dermis (second layer) they were very active, moving around as though seeking out pathogens,” explains Professor Weninger. “Once we established this, it was fascinating to introduce the Leishmania infection and watch as the parasite was picked up by the cells and the process by which it began to spread throughout the body.”

“We now have a general idea of how pathogens are recognised by the immune system and which cells are involved,” Professor Weninger says. “This means we can look at identifying the molecules responsible for the uptake of Leishmania infection and these molecules could become vaccine targets. Additionally, we can investigate the immune responses of other infections which could lead to better vaccines.”

“On the other side of the story, scientists can now visualise the pathway of current vaccines in the immune system, providing greater understanding and the potential for refining current interventions against disease.”

Centenary Institute Executive Director, Professor Mathew Vadas, says the multi-photon microscope used to film this immune process is the Hubble telescope of medical research.

“The Hubble allowed the universe to be seen with absolute clarity, which wasn’t before possible from earth,” he explains. “This is exactly the same as multi-photon microscopy – it provides a unique and innovative view of cells, unveiling a whole new understanding of how immune processes work.”

Source : http://www.centenary.org.au/p/about/media/mediareleases/2008/12/weningerplos/

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First Real-Time MRI of Moving Organs and Joints

First Real-Time MRI of Moving Organs and Joints

First Real-Time MRI of Moving Organs and Joints

“Please hold absolutely still”: This instruction is crucial for patients being examined by magnetic resonance imaging (MRI). It is the only way to obtain clear images for diagnosis. Up to now, it was therefore almost impossible to image moving organs using MRI. Max Planck researchers from Göttingen have now succeeded in significantly reducing the time required for recording images – to just one fiftieth of a second. With this breakthrough, the dynamics of organs and joints can be filmed “live” for the first time: movements of the eye and jaw as well as the bending knee and the beating heart. The new MRI method promises to add important information about diseases of the joints and the heart. In many cases MRI examinations may become easier and more comfortable for patients. (NMR in Biomedicine 2010, Journal of Cardiovascular Magnetic Resonance 2010)

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Real-time MRI of the heart with a measurement time of 33 milliseconds per image and 30 images per second. The spatial… [more]

© Frahm

A process that required several minutes until well into the 1980s, now only takes a matter of seconds: the recording of cross-sectional images of our body by magnetic resonance imaging (MRI). This was enabled by the FLASH (fast low angle shot) method developed by Göttingen scientists Jens Frahm and Axel Haase at the Max Planck Institute for Biophysical Chemistry. FLASH revolutionised MRI and was largely responsible for its establishment as a most important modality in diagnostic imaging. MRI is completely painless and, moreover, extremely safe. Because the technique works with magnetic fields and radio waves, patients are not subjected to any radiation exposure as is the case with X-rays. At present, however, the procedure is still too slow for the examination of rapidly moving organs and joints. For example, to trace the movement of the heart, the measurements must be synchronised with the electrocardiogram (ECG) while the patient holds the breath. Afterwards, the data from different heart beats have to be combined into a film.

Future prospect: extended diagnostics for diseases

The researchers working with Jens Frahm, Head of the non-profit “Biomedizinische NMR Forschungs GmbH”, now succeeded in further accelerating the image acquisition process. The new MRI method developed by Jens Frahm, Martin Uecker and Shuo Zhang reduces the image acquisition time to one fiftieth of a second (20 milliseconds), making it possible to obtain “live recordings” of moving joints and organs at so far inaccessible temporal resolution and without artefacts. Filming the dynamics of the jaw during opening and closing of the mouth is just as easy as filming the movements involved in speech production or the rapid beating of the heart. “A real-time film of the heart enables us to directly monitor the pumping of the heart muscle and the resulting blood flow – heartbeat by heartbeat and without the patient having to hold the breath,” explains Frahm. The scientists believe that the new method could help to improve the diagnosis of conditions such as coronary heart disease and myocardial insufficiency. Another application involves minimally invasive interventions which, thanks to this discovery, could be carried out in future using MRI instead of X-rays. “However, as it was the case with FLASH, we must first learn how to use the real-time MRI possibilities for medical purposes,” says Frahm. “New challenges therefore also arise for doctors. The technical progress will have to be ‘translated’ into clinical protocols that provide optimum responses to the relevant medical questions.”

Less is more: acceleration through better image reconstruction

To achieve the breakthrough to MRI measurement times that only take very small fractions of a second, several developments had to be successfully combined with each other. Whilst still relying on the FLASH technique, the scientists used a radial encoding of the spatial information which renders the images insensitive to movements. Mathematics was then required to further reduce the acquisition times. “Considerably fewer data are recorded than are usually necessary for the calculation of an image. We developed a new mathematical reconstruction technique which enables us to calculate a meaningful image from data which are, in fact, incomplete,” explains Frahm. In the most extreme case it is possible to calculate an image of comparative quality out of just five percent of the data required for a normal image – which corresponds to a reduction of the measurement time by a factor of 20. As a result, the Göttingen scientists have accelerated MRI from the mid 1980s by a factor of 10000.

Although these fast MRI measurements can be easily implemented on today’s MRI devices, something of a bottleneck exists when it comes to the availability of sufficiently powerful computers for image reconstruction. Physicist Martin Uecker explains: “The computational effort required is gigantic. For example, if we examine the heart for only a minute in real time, between 2000 and 3000 images arise from a data volume of two gigabytes.” Uecker consequently designed the mathematical process in such a way that it is divided into steps that can be calculated in parallel. These complex calculations are carried out using fast graphical processing units that were originally developed for computer games and three-dimensional visualization. “Our computer system requires about 30 minutes at present to process one minute’s worth of film,” says Uecker. Therefore, it will take a while until MRI systems are equipped with computers that will enable the immediate calculation and live presentation of the images during the scan. In order to minimise the time their innovation will take to reach practical application, the Göttingen researchers are working in close cooperation with the company Siemens Healthcare.

The desire to visualize noninvasively physiological processes at high temporal resolution has been a driving force for the development of MRI since its inception in 1973. In this article, we describe a unique method for real-time MRI that reduces image acquisition times to only 20 ms. Although approaching the ultimate limit of MRI technology, the method yields high image quality in terms of spatial resolution, signal-to-noise ratio and the absence of artifacts. As proposed previously, a fast low-angle shot (FLASH) gradient-echo MRI technique (which allows for rapid and continuous image acquisitions) is combined with a radial encoding scheme (which offers motion robustness and moderate tolerance to data undersampling) and, most importantly, an iterative image reconstruction by regularized nonlinear inversion (which exploits the advantages of parallel imaging with multiple receiver coils). In this article, the extension of regularization and filtering to the temporal domain exploits consistencies in successive data acquisitions and thereby enhances the degree of radial undersampling in a hitherto unexpected manner by one order of magnitude. The results obtained for turbulent flow, human speech production and human heart function demonstrate considerable potential for real-time MRI studies of dynamic processes in a wide range of scientific and clinical settings. Copyright © 2010 John Wiley & Sons, Ltd.

source : http://www.mpg.de/620403/pressRelease20100830

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